After Domonic Brown hit a solo home run in the top of the second inning to tie the game at 1-1, Marlins starter Alex Sanabia received a new baseball from home plate umpire Sam Holbrook and promptly glazed it with spit as seen here:
Given the various gymnastics that can occur within MLB’s rules, there might be a loophole, but if my reading of the rules is correct, Sanabia violated Rule 8.02 (a)(2):
The pitcher shall not —
(2) expectorate [spit] on the ball, either hand or his glove;
You can watch the whole event here, with the infraction occurring about 15 seconds in.